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SFN functions by inhibiting and enhancing phase I enzymes interacting with cytochrome P450 and phase II enzymes by activating Nrf2 (Nuclear factor E2-factor related factor) (96) (Figure 2)

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Animal experiments and protocols conformed to the Guide for the Care and Use of Laboratory Animals (US National Institutes of Health), the Swiss animal protection laws and were approved by the Cantonal Veterinary Office in Zurich, Switzerland (study number 186/2017)

1101-9, PMID 7882173